UAC Seminar: Anders Nilsson + Hannah Bradby
- Date: –16:00
- Location: Biomedicinskt centrum, BMC C8:301
- Lecturer: Anders Nilsson + Hannah Bradby & Hedvig Gröndal
- Organiser: Uppsala Antibiotic Center
- Contact person: Eva Garmendia
- Phone: 018-471 4902
Welcome to our last UAC seminar of the year. This time we will have phage therapy and public health as topics on this double-feature seminar.
Anders Nilsson: "Phage (therapy) infection biology"
Phages are ubiquitous in all environments, including the human body, and presumably encompass the largest amount of genetic variation on earth. Despite this, their biology, importance for the balance of ecosystems, and human health is only beginning to be understood. Mathematical models of phage infections could potentially contribute to a better understanding and optimization of phage therapy regimens, and shed some light on the problem of inconsistency between in vitro trials and phage therapy experiences. It is difficult to generalize the infection kinetics and dynamics of different phage – bacteria combinations and many infection parameters are either virtually unknown or too difficult to add to current mass-action models. As a consequence, the predictability of mathematical models on the kinetics and results of even simple in vitro phage infection experiments is often poor. At present, many infection parameters e.g. the importance of spatial heterogeneity of hosts, kinetics of biofilm formation, lowered adsorption rate due to binding to bacterial debris, distribution among cells (for instance of different age or at varying resource availability) of phage infection virulence parameters are not part of any coherent model. We have started to develop new software with the aim to explore which infection parameters that matters most and to work towards closing the gap between models and empirical results. Another goal is that the development results in an easy to use computer program that can be further refined continuously as more data becomes available.
Hanna Bradby & Hedvig Gröndal: ‘Irrational and rational public health interventions: attending to patients, populations and policy’
Stewardship approaches to antimicrobial resistance will be contextualized in previous public health campaigns that make use of education and behavior change. The tensions between population and patient benefit and between different meanings of antibiotic prescribing will be sketched to describe various forms of risk and knowledge.